Schizophrenia Research Studies

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Study Seeking Patients with Schizophrenia in San Diego

Eligibility Criteria: To be considered for participation, you must meet the following requirements:

• Age between 18 and 65 years
• Clinically diagnosed with Schizophrenia
• Open to taking study medication or participating in research activities
• Agreeable to undergo physical examinations and have vital signs measured

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There are an estimated 2.4 million adults living with schizophrenia in the United States today and that number continues to grow. It often appears in males in their late teens or early twenties and in females in their late twenties or early thirties. The symptoms of schizophrenia can be very different from one person to the next so finding the cause of this mental illness has proved to be difficult.

Clinical Definition of Schizophrenia

Schizophrenia is defined as a chronic and severe mental disorder that distorts the way individuals perceive the world. Those affected may experience a blend of hallucinations, delusional thoughts, and impaired reasoning, making daily activities and routines challenging to navigate.

If you or someone you know is interested in participating in a clinical research study for schizophrenia, or if you would like more information, please reach out to us directly. Please fill out the form or contact us today.

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The symptoms of schizophrenia generally fall into two main categories: positive symptoms, which involve the distortion of normal behaviors and functioning, and negative symptoms, which reflect an absence of normal behaviors and functioning. The severity and scope of the symptoms will vary from person to person. 

Positive symptoms

Positive symptoms of schizophrenia often reflect the altered perception experienced by the individual. These are symptoms that are distortions or changes to normal functioning. They include: 

• Hallucinations – hearing or seeing things that aren’t there
• Delusions – beliefs that are not supported by objective facts
• Disorganized and unpredictable behavior – problems with routine tasks, inconsistent or childlike behavior, inappropriate responses
• Confused thoughts and speech – illogical thinking, trouble concentrating and keeping track of thoughts, jumbled speech and difficulty with conversations
• Catatonic behavior – may involve odd and exaggerated movements, repetitive movements,  a rigid body posture, sometimes punctuated by brief episodes of excitability

Positive symptoms can be very frightening and often cause a great deal of distress to both the individual afflicted with schizophrenia and those around them. Positive symptoms often overshadow negative symptoms because of their overt nature, but they also tend to respond more favorably to medication and other forms of treatment than negative symptoms do. 

Negative symptoms

Negative symptoms present as the absence or minimization of normal behaviors. These may include:  

• A lack of expressiveness
• Blank looks
• Lack of eye contact
• Monotone speech
• Emotional unresponsiveness
• A lack of enthusiasm or pleasure
• A lack of will or spontaneity
• Loss of concentration
• Lack of motivation
• Social withdrawal

Negative symptoms can be difficult to notice when positive symptoms are uncontrolled—they often become more evident once the positive symptoms have been treated or have otherwise diminished. Negative symptoms are also very troubling, and they tend to be less responsive to medications and therapies, making it difficult for the individual to live a healthy and productive life. 

Further schizophrenia research is needed to help advance science and provide more treatment options for the management of positive and negative symptoms. 

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Cognitive impairments are another core feature present in the majority of schizophrenia patients. Cognitive impairments related to schizophrenia tend to become more noticeable once the positive and psychotic symptoms have been treated. The severity and scope of cognitive impairments vary from person to person, but symptoms typically include one or more of the following:

• Difficulty paying attention
• Memory dysfunction (especially verbal working memory)
• Poor learning and retention of verbal information
• Inflexible thinking and trouble adapting to changes in the environment
• Difficulty with planning

Unlike positive symptoms of schizophrenia, which tend to fluctuate, cognitive symptoms remain fairly stable.  Some patients have had success in minimizing the effects of these cognitive impairments through a combination of behavioral therapies and medication. 

[/fusion_toggle][fusion_toggle title=” Acute Schizophrenia” open=”no” class=”” id=””]

Schizophrenia typically cycles through three phases: prodromal, acute, and residual. The phases repeat and cycle in order, though each individual will have their own unique experience with both the symptoms and the duration of each phase. Acute schizophrenia, also known as active schizophrenia, refers to the phase of the disorder that exhibits the most visible signs and symptoms. The symptoms during the prodromal and residual phases tend to be less severe than the symptoms that take place during the acute phase. Acute schizophrenia is recognized as active psychosis, when the individual has lost touch with reality.  During these episodes, any combination of positive, negative, and cognitive symptoms may be present, and normal functioning is extremely difficult. The goals of treatment during the acute phase include: 

• Prevent harm
• Control disturbed behavior
• Reduce the severity of the symptoms
• Determine and address the factors that led to the exacerbated symptoms

Hospitalization is often required during the acute phase, in order to reduce overstimulation, monitor for dangerous behaviors and other risk factors, and stabilize the individual. 

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CBD Oil and Schizophrenia:

Recent research investigates CBD oil’s potential therapeutic effects on schizophrenia symptoms, despite the known risks of schizophrenia associated with heavy cannabis use.
The brain’s complexity and the mysteries surrounding mental illnesses like schizophrenia underscore the urgency of ongoing brain research. Significant advancements have been made in understanding schizophrenia, including its association with cannabis use and the potential benefits of CBD oil.

learn more about CBD and schizophrenia

Schizophrenia Outpatient Trials San Diego CA

Synergy Research Centers in San Diego is committed to discovering more effective treatments for schizophrenia symptoms through outpatient studies. These studies involve non-hospitalized individuals with schizophrenia and test new treatments to evaluate their efficacy. We are actively seeking participants for our schizophrenia outpatient trials. To learn more, please contact us or fill out a form. or give us a call at (888) 619-7272.

Who is Eligible to Participate in a Schizophrenia Study?

Synergy Research Centers in Lemon Grove conducts both inpatient and outpatient research studies for individuals diagnosed with schizophrenia. Eligibility criteria include being at least 18 years old, with varying age limits across different studies. Prospective participants can undergo further screening by contacting our office to determine their eligibility for a study.

Focus of the Schizophrenia Research Trials

The primary goal of these trials is to identify more effective treatments for managing schizophrenia, a condition currently without a cure. Although various medications are available, they often fall short in fully addressing the debilitating symptoms of schizophrenia. At Synergy Research Centers, our aim is to find treatments that improve the quality of life for those living with schizophrenia.

*Participants in the study may receive a stipend for each visit, and transportation is provided for select studies.

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